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  • Title: Association of the C-399T promoter polymorphism of neuropeptide Y with susceptibility to ischemic stroke.
    Author: Kim NS, Oh SM, Ko MM, Cha MH, Kang BK, Bang OS.
    Journal: Clin Biochem; 2009 Nov; 42(16-17):1699-704. PubMed ID: 19619519.
    Abstract:
    OBJECTIVES: The common sequence variants of neuropeptide Y (NPY) were known to be associated with some kinds of diseases including stroke. This study investigated the association of NPY promoter polymorphism, C-399T, with ischemic stroke and its underlying mechanism using in vitro systems. DESIGN AND METHODS: Study subjects consisted of 444 ischemic stroke patients and 326 controls without stroke. C-399T genotyping was conducted by a primer extension-based method. Plasma NPY was quantified with an enzyme immunoassay, and transcription characteristics were investigated by a reporter gene assay and an enzyme mobility shift assay. RESULTS: A significantly lower frequency of TT genotype was observed in a stroke group (OR[95% CI], 0.399[0.187-0.854], p=0.0180). The C-399T polymorphism affected the transcription efficiency of NPY gene and its genotypes were related to the changes in plasma NPY levels. CONCLUSION: This study suggests that NPY promoter polymorphism, C-399T, should be considered a genetic risk factor for ischemic stroke.
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