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  • Title: [Expression of annexin V in decidua tissues of preeclampsia patients].
    Author: Feng YL, Zhou CJ, Xue M.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2009 Jul; 29(7):1438-41. PubMed ID: 19620076.
    Abstract:
    OBJECTIVE: To investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance. METHODS: Real-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients. RESULTS: Annexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group. CONCLUSION: The low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.
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