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  • Title: Virulence of pneumococcal proteins on the inner ear.
    Author: Schachern PA, Tsuprun V, Cureoglu S, Ferrieri P, Briles DE, Paparella MM, Juhn S.
    Journal: Arch Otolaryngol Head Neck Surg; 2009 Jul; 135(7):657-61. PubMed ID: 19620586.
    Abstract:
    OBJECTIVE: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. MAIN OUTCOME MEASURES: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. RESULTS: Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal. CONCLUSIONS: Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.
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