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  • Title: [Minimization or avoidance of calcineurin inhibitors after renal transplantation].
    Author: Xue C, Ji ZG.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2009 Jun; 31(3):280-3. PubMed ID: 19621509.
    Abstract:
    Calcineurin inhibitors (CNIs) are playing an important role in preventing acute rejection in renal transplantation; however, their nephrotoxicity may impact long-term renal allograft survival. Several CNI-sparing regimens (such as CNI-avoidance or CNI-minimization) have shown at least comparable efficacy with standard-dose CNI regimens. Research continues to achieve the "best" balance between efficacy and toxicity of available immunosuppressive regimens.
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