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  • Title: Clinical course and indications for steroid therapy of sclerosing cholangitis associated with autoimmune pancreatitis.
    Author: Nakazawa T, Ohara H, Ando T, Hayashi K, Naitoh I, Okumura F, Tanaka H, Sano H, Joh T.
    Journal: Hepatogastroenterology; 2009; 56(91-92):584-8. PubMed ID: 19621659.
    Abstract:
    BACKGROUND/AIMS: There have been only a few reports about the clinical course and indications for steroid therapy of autoimmune pancreatitis (AIP). We studied 45 cases of AIP to clarify the clinical course and indications for steroid therapy, from the viewpoint of associated sclerosing cholangitis (SC). METHODOLOGY: Two groups (with and without progression or recurrence) were compared by cholangiographic classification, blood chemistry, initial therapy, presenting symptoms and pancreatic findings. RESULTS: One patient with AIP and no stricture and seven patients with AIP and SC with stricture of the lower common bile duct showed strictures of the intrahepatic bile duct and hilar hepatic lesions during their clinical course. SC patients with intrahepatic stenosis showed higher IgG levels than those with stenosis of the lower common bile duct only. Six of seven cases without steroid therapy and IgG >2000 mg/dL showed significantly greater recurrence or progression of SC. CONCLUSIONS: When a patient with SC and AIP with elevated levels of IgG (>2000 mg/dL) is encountered, steroid administration should be initiated immediately.
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