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  • Title: Pyridoxal 5'-phosphate binding in lysine-modified PAMAM dendrimers: a biomimetic approach.
    Author: Hsien KC, Chen HT, Chen YC, Chen YL, Lu CY, Kao CL.
    Journal: Org Lett; 2009 Aug 20; 11(16):3526-9. PubMed ID: 19621874.
    Abstract:
    (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)(x) (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5'-phosphate. The results revealed a positive dendritic effect, and binding ability was found to vary with the environment. (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)(x) (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding. The strongest binding affinity was K(b) = 254.3 mM(-1) at pH 9, which was shown by (G:7)-dendri-PAMAM-(APO-Phe-Lys)(490) (2e).
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