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  • Title: Efficient and stereoselective access to the polyol fragment C9-C16 of ansamycin antibiotics.
    Author: Obringer M, Barbarotto M, Choppin S, Colobert F.
    Journal: Org Lett; 2009 Aug 20; 11(16):3542-5. PubMed ID: 19624101.
    Abstract:
    Efficient synthesis of the fragment C9-C16 bearing the anti,syn stereotriad of ansamycin antibiotics is described. Key steps for controlling the configuration of the three stereogenic centers involve a stereoselective Reformatsky-type reaction followed by a diastereoselective reduction of a beta-ketosulfoxide.
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