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  • Title: Oral lichen planus and chronic junctional stomatitis: differences in lymphocyte subpopulations.
    Author: Omar AA, Hietanen J, Kero M, Lukinmaa PL, Hagström J.
    Journal: Acta Odontol Scand; 2009; 67(6):366-9. PubMed ID: 19626466.
    Abstract:
    OBJECTIVE: Oral lichen planus (OLP) is an oral counterpart or oral manifestation of the common skin disease lichen planus. Chronic junctional stomatitis (CJS) is a relatively unknown condition characterized by a stromal lymphocyte infiltrate, which is also a diagnostic feature of OLP. The differential diagnosis of OLP and CJS is unclear and they have been suggested to represent variants of the same disease. MATERIAL AND METHODS: To investigate possible differences in lymphocyte (sub)populations between these two conditions, we immunostained 10 OLP and 10 CJS specimens for CD1-a, and the lymphocyte markers, CD3, CD4, CD5, CD8, and CD20. We scored the staining results by a four-step grading system and used the Fisher exact test to analyze them statistically. RESULTS: The proportional amount of (CD20 positive) B lymphocytes was higher in CJS than in OLP and the predominance of CD4 positive T lymphocytes over CD8 positive T lymphocytes was stronger in OLP than in CJS. The differences were statistically significant. CONCLUSION: The results reflect differences in the lymphatic infiltrate between OLP and CJS. Their significance needs further investigation.
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