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  • Title: Affinity study of novel gelatin cell carriers for fibronectin.
    Author: Van Vlierberghe S, Vanderleyden E, Dubruel P, De Vos F, Schacht E.
    Journal: Macromol Biosci; 2009 Nov 10; 9(11):1105-15. PubMed ID: 19626719.
    Abstract:
    In the present work, the gelatin/fibronectin affinity was evaluated using SPR, QCM and radiolabelling. The results indicate that type A gelatin films possess a higher affinity for Fn compared to type B gelatin. This is due to a combined hydrophobic and electrostatic interaction between gelatin type A and Fn. In a second part, the affinity of Fn for porous gelatin scaffolds was evaluated. The scaffolds were prepared by a cryogenic treatment and subsequent freeze-drying yielding type I and type II scaffolds which possess different pore geometries/sizes. The results indicate that the Fn density on the scaffolds can be fine-tuned by varying the Fn concentration, the gelatin type (A vs. B), the pore size/geometry (type I vs. type II scaffolds).
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