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  • Title: Comparison of surgical wound infection after preoperative skin preparation with 4% chlorhexidine [correction of chlohexidine] and povidone iodine: a prospective randomized trial.
    Author: Paocharoen V, Mingmalairak C, Apisarnthanarak A.
    Journal: J Med Assoc Thai; 2009 Jul; 92(7):898-902. PubMed ID: 19626807.
    Abstract:
    BACKGROUND: Antiseptic scrub and paint can reduce bacterial colonization and postoperative wound infection. Two forms of antiseptics, povidone iodine and chlorhexidine, are commonly used in the operating theater. OBJECTIVE: To study the efficacy of the reduction of bacterial colonization and surgical wound infection among these antiseptic. MATERIAL AND METHOD: Five hundred surgical patients were randomly divided into two groups. Povidone Iodine and Chlorhexidine were used for skin preparation in group 1 and 2 respectively Bacterial colonization and postoperative wound infection were examined after skin preparation. Demographic data was analyzed by student's t test; the culture result and surgical wound infection were analyzed by Mantel-Haenszel method for relative risk and 95% CI. RESULTS: There was a significant reduction of bacterial colonization and wound infection after skin preparation in group 2 compared with group 1. CONCLUSION: Colonization of bacterial and postoperative surgical wound infection were significantly reduced in the chlorhexidine group. Chlorhexidine antiseptic should be the first consideration for preoperative skin preparation.
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