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  • Title: [Effects of natural plant ginkgolic acids on the apoptosis of human Hep-2 cancer cells].
    Author: Zhou CC, Du W, Wen Z, Li JY, Zhang P.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 May; 40(3):459-61. PubMed ID: 19627005.
    Abstract:
    OBJECTIVE: To investigate the anti-cancer effects and mechanism of natural plant ginkgolic acids (GAs) on Human Hep-2 cancer cells. METHODS: Hep-2 cancer cells were treated with different concentration of GAs for different times. The proliferation of Hep-2 cancer cells were detected by MTT colorimetric assay. Biochemistry characteristics of cell apoptosis was analyzed by DNA agarose electrophoresis and FCM. RESULTS: The proliferation of Hep-2 cancer cells were inhibited significantly by GAs in a dose and time-dependent manner. Typical DNA ladder bands of Hep-2 cell DNA treated with GAs were observed on agarose electrophoresis gels. Increased apoptosis of Hep-2 cells treated with GAs was also noticed with FCM analysis. CONCLUSION: Ginkgolic acids show an anti-tumor activity through inhibition the growth and inducing apoptosis of tumor cell in vitro.
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