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  • Title: Intestinal lengthening in rats after massive small intestinal resection.
    Author: Shekherdimian S, Scott A, Chan A, Dunn JC.
    Journal: Surgery; 2009 Aug; 146(2):291-5. PubMed ID: 19628087.
    Abstract:
    BACKGROUND: Prior studies have demonstrated lengthening of normal small intestinal segments using mechanical expanders. The present study assesses the feasibility of intestinal lengthening in rats that have undergone extensive small intestinal resection. METHODS: Female rats underwent small intestinal resection. After 6 weeks, the animals underwent the placement of a mechanical expander device with or without gradual mechanical lengthening. After 3 weeks, the intestinal segments were retrieved for analyses. RESULTS: Isolated intestinal segments without mechanical lengthening did not change in length, whereas isolated intestinal segments that were mechanically lengthened more than doubled their initial length. The total alkaline phosphatase activity was 2.4 mumol/min in the isolated intestinal segments and 4.9 mumol/min in the mechanically lengthened segments. The total lactase activity was 0.005 mumol/min in the isolated intestinal segments and 0.007 mumol/min in the mechanically lengthened segments. Smooth muscle thickness was 370 mum in the isolated intestinal segments and 530 mum in the mechanically lengthened segments. CONCLUSION: Mechanical small bowel lengthening was achieved in intestinal segments after extensive small intestinal resection. There was an increase in the total alkaline phosphatase activity and preservation of the total lactase activity. Mechanical lengthening may be a useful technique to increase intestinal length in patients with short bowel syndrome.
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