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  • Title: Effect of low molecular weight heparin preparations on the inhibition of thrombin by heparin cofactor II.
    Author: Tollefsen DM, Sugimori T, Maimone MM.
    Journal: Semin Thromb Hemost; 1990 Oct; 16 Suppl():66-70. PubMed ID: 1962908.
    Abstract:
    1. Heparin molecules approximately 24 to 30 residues in length are required to catalyze the thrombin-HC II reaction. The requirement for heparin molecules of this length is consistent with a model for catalysis in which heparin binds HC II and thrombin simultaneously to form a ternary complex in a manner similar to that proposed for the thrombin-AT III reaction. Smaller molecules (18 or more monosaccharide units in length) are required to catalyze the thrombin-AT III reaction. 2. The specific AT III-binding pentasaccharide containing 3-O-sulfated glucosamine is not required for activity with HC II. 3. Some low molecular weight heparin preparations have significant activity with HC II (approximately 10 to 20% that of standard heparin). This is probably related to the presence of species with molecular weights greater than 6000 to 7500 (24 to 30 monosaccharide units) in these preparations.
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