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  • Title: Detection of bone metastases in non-small cell lung cancer patients: comparison of whole-body diffusion-weighted imaging (DWI), whole-body MR imaging without and with DWI, whole-body FDG-PET/CT, and bone scintigraphy.
    Author: Takenaka D, Ohno Y, Matsumoto K, Aoyama N, Onishi Y, Koyama H, Nogami M, Yoshikawa T, Matsumoto S, Sugimura K.
    Journal: J Magn Reson Imaging; 2009 Aug; 30(2):298-308. PubMed ID: 19629984.
    Abstract:
    PURPOSE: To prospectively compare the capability for bone metastasis assessment of whole-body diffusion-weighted imaging (DWI), magnetic resonance imaging (MRI) without and with DWI, [(18)F] fluoro-2-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) and bone scintigraphy in non-small cell carcinoma (NSCLC) patients. MATERIALS AND METHODS: In all, 115 consecutive NSCLC patients (66 men, 49 women; mean age 72 years) prospectively underwent whole-body MRI, PET/CT, and bone scintigraphy before treatment. For each method, probability of metastasis was independently assessed by using a 5-point visual scoring system on a per-site basis. Receiver operating characteristic (ROC)-based positive tests were used to determine the practical threshold value for each method on a per-site basis. Sensitivities, specificities, and accuracies were then compared on a per-site and per-patient basis by means of McNemar's test. RESULTS: When the practical threshold values were adapted, specificity and accuracy of whole-body MRI with DWI were significantly higher than those of bone scintigraphy and PET/CT (P < 0.05). On a per-patient basis, specificity and accuracy of whole-body MRI with DWI were significantly higher than those of bone scintigraphy (P < 0.05). CONCLUSION: Whole-body MRI with DWI can be used for bone metastasis assessment of NSCLC patients as accurate as bone scintigraphy and/or PET/CT.
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