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  • Title: Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase.
    Author: Jogo M, Shiraishi S, Tamura TA.
    Journal: FEBS Lett; 2009 Sep 03; 583(17):2715-9. PubMed ID: 19631210.
    Abstract:
    Myogenesis is conducted by transcription factors including MyoD and myogenin. Myogenin is known to be polyubiquitinated by SCF (Skp1/Cullin 1/F-box protein) followed by proteasomal degradation, though the participating F-box protein is remaining unidentified. In this study, we found that myogenin in differentiated myoblasts is destabilized by muscle atrophy-inducing dexamethasone and that MAFbx (muscle atrophy F-box protein) is increased in atrophying myotubes. MAFbx overexpression resulted in MG132-sensitive reduction of myogenin. Myogenin had a MAFbx-recognition motif and interacted with MAFbx. MAFbx activated polyubiquitination of myogenin. The results of this study suggest that MAFbx functions as an F-box protein for ubiquitination of myogenin.
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