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  • Title: Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.
    Author: Padmaja A, Payani T, Reddy GD, Padmavathi V.
    Journal: Eur J Med Chem; 2009 Nov; 44(11):4557-66. PubMed ID: 19631423.
    Abstract:
    A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.
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