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  • Title: Design and optimisation of potent gp120-CD4 inhibitors.
    Author: Tran TD, Adam FM, Calo F, Fenwick DR, Fok-Seang J, Gardner I, Hay DA, Perros M, Rawal J, Middleton DS, Parkinson T, Pickford C, Platts M, Randall A, Stephenson PT, Vuong H, Williams DH.
    Journal: Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5250-5. PubMed ID: 19632839.
    Abstract:
    The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibitor which exhibited antiviral potency across a spectrum of 25 clade B isolates.
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