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  • Title: [Genetic epidemiology of esophageal cancer: 10-year follow-up of 622 positive families in Yangcheng County].
    Author: Hu N.
    Journal: Zhonghua Yi Xue Za Zhi; 1990 Dec; 70(12):679-81, 46. PubMed ID: 1963371.
    Abstract:
    Follow-up survey of 622 esophageal cancer (EC) positive families found during 1978-1979 was carried out in 1989 in a total of 5037 families. During this period (1978-1988), 35.8% of new EC deaths were found from 393 families with two or more EC deaths which accounted for only 7.8% (393/5037) of the total families. When the EC positive families were divided into three groups with 1, 2 and greater than or equal to 3 EC deaths in each, the EC deaths among offsprings of EC free parents were 6.7%, 11.1%, and 15.7% respectively. Offsprings from households with one parent died of EC belonging to family groups with 2 or greater than or equal to 3 EC deaths had different EC frequencies (9.5% versus 22.8%). In 184 families with greater than or equal to 3 EC deaths, offsprings from households with one or both parents died of EC showed also higher EC mortality (22.8% and 22.7% respectively) than those from households with EC free parents (15.7%). These results pointed to a strong tendency of familial aggregation of EC and the existence of genetically determined susceptibility to this human malignancy.
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