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  • Title: Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacin.
    Author: Sugawara I, Zhang J, Li C.
    Journal: Indian J Exp Biol; 2009 Jun; 47(6):520-2. PubMed ID: 19634718.
    Abstract:
    Seventy-four streptomycin (SM)-resistant M. tuberculosis clinical isolates were subjected to cross-resistance drug testing against two major aminoglycosides, kanamycin (KM) and amikacin (AMK). Among them, 15 clinical isolates (20.3%) were resistant to both KM and AMK. Fifteen (80%) of 19 KM-resistant isolates were AMK-resistant. Fifteen SM, KM, and AMK resistant isolates harbored rrs mutation, but only two had rrs and rpsL double mutations. Low-level SM resistance was associated with rpsL mutation, whereas high-level SM resistance was linked to rrs mutation.
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