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  • Title: Sequential five-component synthesis of spiropyrrolidinochromanones.
    Author: Marcaccini S, Neo AG, Marcos CF.
    Journal: J Org Chem; 2009 Sep 04; 74(17):6888-90. PubMed ID: 19634867.
    Abstract:
    Herein we report a novel, diastereoselective, one-pot, two-step, sequential synthesis of highly functionalized natural product-like spiropyrrolidinochromanones. The process consists of an Ugi four-component condensation of 3-formylchromones with amines, isocyanides, and glyoxylic acids followed by a nucleophilic conjugate addition and intramolecular cyclization. The experimental simplicity and tolerance to a wide variety of substituents makes this method suitable for combinatorial synthesis.
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