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  • Title: [Effect of endotoxin on aggregation and release of human platelet in vitro].
    Author: He K, Liou HQ.
    Journal: Sheng Li Xue Bao; 1990 Dec; 42(6):591-4. PubMed ID: 1963501.
    Abstract:
    The effect of endotoxin on human platelet was studied in vitro. E Coli O55B5 endotoxin inhibited spontaneous platelet aggregation but had no effect on platelet aggregation by epinephrine and the release of contents from dense granule, alpha-granule of platelet. The endotoxin also elevated cAMP and increased the activity of calmodulin in platelet, which might account for the effect of the endotoxin on platelet. In addition, a reduced concentration of 5-HT in the supernate of endotoxin group was also observed.
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