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  • Title: Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.
    Author: Xu P, Zhang YY, Sun YX, Liu JH, Yang B, Wang YZ, Wang YL.
    Journal: Chem Biol Drug Des; 2009 Jun; 73(6):655-60. PubMed ID: 19635057.
    Abstract:
    Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.
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