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  • Title: Diagnostic test validation: cochlear hydrops analysis masking procedure in Ménière's disease.
    Author: Ordóñez-Ordóñez LE, Rojas-Roncancio E, Hernández-Alarcón V, Jaramillo-Safón R, Prieto-Rivera J, Guzmán-Durán J, Lora-Falquez J, Escobar M, Angulo-Martínez ES.
    Journal: Otol Neurotol; 2009 Sep; 30(6):820-5. PubMed ID: 19638943.
    Abstract:
    OBJECTIVE: To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease. STUDY DESIGN: Prospective validation study for a diagnostic test, study phase 2. SETTING: Tertiary referral centers. PATIENTS: Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated. INTERVENTIONS: Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery. MAIN OUTCOME MEASURE: Sensitivity, specificity, and other indicators of diagnostic validation. RESULTS: One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001). CONCLUSION: If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.
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