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  • Title: 7,7-Dimethylaporphine alkaloids from the stem of Guatteriopsis friesiana.
    Author: Costa EV, Marques FA, Pinheiro ML, Vaz NP, Duarte MC, Delarmelina C, Braga RM, Maia BH.
    Journal: J Nat Prod; 2009 Aug; 72(8):1516-9. PubMed ID: 19639965.
    Abstract:
    Phytochemical investigation of a methanolic extract of the stem of Guatteriopsis friesiana afforded two new 7,7-dimethylaporphine alkaloids, 6,6a-dihydrodemethoxyguadiscine (1) and guatteriopsiscine (3), together with demethoxyguadiscine (2), liriodenine (4), corypalmine (5), and coreximine (6). Their structures were elucidated on the basis of spectroscopic methods (UV, IR, EIMS, HRESIMS, 1D/2D NMR). The absolute configurations of 1 and 3 were determined from the circular dichroism curves. The presence of 7,7-dimethylaporphine alkaloids in this species is important for the chemotaxonomy of Guatteriopsis. Antimicrobial activity of compounds 1-5 was investigated, and 4 showed activity against Rhodococcus equi, with a MIC value of 10 microg x mL(-1).
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