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  • Title: [2.2]Paracyclophane-based monophosphine ligand for palladium-catalyzed cross-coupling reactions of aryl chlorides.
    Author: Ruan J, Shearer L, Mo J, Bacsa J, Zanotti-Gerosa A, Hancock F, Wu X, Xiao J.
    Journal: Org Biomol Chem; 2009 Aug 21; 7(16):3236-42. PubMed ID: 19641780.
    Abstract:
    A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides are shown to be viable substrates. However, the Suzuki-Miyaura coupling appears to be easier, with palladium loading at 0.1 mol% being feasible.
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