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  • Title: Quantification of D-Asp and D-Glu in rat brain and human cerebrospinal fluid by microchip electrophoresis.
    Author: Huang Y, Shi M, Zhao S.
    Journal: J Sep Sci; 2009 Sep; 32(17):3001-6. PubMed ID: 19642099.
    Abstract:
    A microchip electrophoresis (MCE) method with LIF detection was presented for quantification of D-aspartic acid (D-Asp) and D-glutamate (D-Glu) in biological samples. D-Asp and D-Glu were determined after precolumn derivatization with FITC. The chiral separation was performed on a glass/PDMS hybrid microfluidic chip using gamma-CD as chiral selector in the running buffer. High sensitive detection was obtained by the LIF detection. The LODs (S/N = 3) for D-Asp and D-Glu were 6.0x10(-8) and 4.0x10(-8) M, respectively. Using this method, the levels of D-Asp and D-Glu in rat brain and human cerebrospinal fluid (CSF) were determined.
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