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  • Title: [The clinical and laboratory characteristics of T cell large granular lymphocyte leukemia].
    Author: Zhao X, Zhou K, Wang HJ, Zhang L, Liu QG, Jing LP, Li HQ, Yang DL, Chu YL, Zhang FK.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2009 Mar; 30(3):179-82. PubMed ID: 19642367.
    Abstract:
    OBJECTIVE: To analyze the characteristics of T-cell large granular lymphocyte leukemia (T-LGLL). METHODS: Retrospectively analyze the clinical and laboratory data of 27 patients with T-LGLL diagnosed between 1999 and 2007 in our hospital. RESULTS: The median age at diagnosis was 48 years. All patients were symptomatic, mainly complaining of fatigue. Of the 27 patients, 14 (51.9%) had splenomegaly, and 4(14.8%) hepatomegaly. Rheumatoid arthritis was not present in any patients. The most frequent hematological abnormality was anemia (24 patients, 88.9%) with a median Hb level of 57.5 g/L. Pure red cell aplasia was found in 18 patients (66.67%). The median WBC count was 4.24 x 10(9)/L and 19 cases were neutropenia (ANC < 1.5 x 10(9)/L). The median LGL count in peripheral blood was 1.45 x 10(9)/L and most of them (77.8%) were less than 2.0 x 10(9)/L. Twenty-two patients (81.5%) showed the CD3+ CD8+ CD57+ CD56(-) LGL phenotype. With immunosuppressive therapy, 91.3% of patients responded and complete hematological remission rate was 65.2%. CONCLUSION: T-LGLL mainly presented with anemia and complete hematological remission rate was 65.2%. Pure red cell aplasia was commonly associated with the disease. The patients had a good response to immunosuppressive therapy.
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