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  • Title: [Structural and functional organization of the cerebral dopaminergic system].
    Author: Barishpolets VV, Fedotova IuO, Sapronov NS.
    Journal: Eksp Klin Farmakol; 2009; 72(3):44-9. PubMed ID: 19642593.
    Abstract:
    The structural and functional organization of the cerebral dopaminergic system is considered. The synthesis of dopamine, distribution of dopaminergic structures, structure and classification of dopamin receptors in the brain, and functions of dopamine are discussed. Dopamin among the main catecholamine neurotransmitters participating in the control of locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. Moreover, several neurological diseases such as Parkinson's disease, schizophrenia, and hyperprolactinemia are associated with dysregulation of dopaminergic neurotransmission. Therefore, the search for and development of new dopaminergic drugs is of great interest.
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