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  • Title: Steroidal glycosides from Agave utahensis and their cytotoxic activity.
    Author: Yokosuka A, Jitsuno M, Yui S, Yamazaki M, Mimaki Y.
    Journal: J Nat Prod; 2009 Aug; 72(8):1399-404. PubMed ID: 19645463.
    Abstract:
    Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.
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