These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
    Author: Vergara FM, Henriques Md, Candea AL, Wardell JL, De Souza MV.
    Journal: Bioorg Med Chem Lett; 2009 Sep 01; 19(17):4937-8. PubMed ID: 19648006.
    Abstract:
    A series of 11 alpha,omega-diaminoalkanes, (H(2)N(CH(2))(n)NH(2), n=2-12) have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Compounds, (H(2)N(CH(2))(n)NH(2), n=9-12), exhibited a very good activities in the range 2.50-3.12 microg/mL, which can be compared with that of the first line drug, ethambutol (3.12 microg/mL). These results and a preliminary QSAR study can be considered an important start point for the rational design of new leads for anti-TB compounds.
    [Abstract] [Full Text] [Related] [New Search]