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  • Title: Click chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivatives.
    Author: Mohapatra DK, Maity PK, Shabab M, Khan MI.
    Journal: Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5241-5. PubMed ID: 19648009.
    Abstract:
    We describe herein a one-pot synthesis of novel tetracyclic scaffolds that incorporate a fusion of a proline, 1,2,3-triazole ring with [1,4]-benzodiazepin-8(4H)-one ring systems following click chemistry. The expected peptide bond formation followed by in situ 1,3-dipolar cycloaddition in absence of any catalyst led to the formation of new triazole fused benzodiazepine derivatives.
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