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  • Title: Primary hyperparathyroidism presenting as anticonvulsant-induced osteomalacia.
    Author: Broadus AE, Hanson TA, Bartter FC, Walton J.
    Journal: Am J Med; 1977 Aug; 63(2):298-305. PubMed ID: 196503.
    Abstract:
    A patient presented with the classic features of anticonvulsant-induced osteomalacia. Following discontinuance of diphenylhydantoin therapy and repletion with physiologic quantities of vitamin D, hypercalcemia and persistent biochemical hyperparathyroidism developed, and a parathyroid adenoma was removed. A history of nephrolithiasis and hypercalcemia preceding the institution of drug therapy allowed this patient's underlying parathyroid disease to be defined as primary hyperparathyroidism, which had been obscured by anticonvulsant therapy.
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