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  • Title: Structural changes in the freeze-fractured sarcolemma of ischemic myocardium.
    Author: Ashraf M, Halverson CA.
    Journal: Am J Pathol; 1977 Sep; 88(3):583-94. PubMed ID: 196504.
    Abstract:
    Ultrastructural alterations in the sarcolemma of ischemic myocardium were studied with the freeze-fracture technique. In normal myocardial sarcolemma, the P fracture face contained many intramembranous particles which were randomly distributed, while the E fracture face had few intramembranous particles; no structural abnormalities were seen within the lipid bilayer on either face. Myocardium ischemic for 45 minutes displayed no, or only slight, aggregation of intramembranous particles, but upon reperfusion for 5 to 20 minutes, the particles became significantly aggregated in the P face. Scattered nicks within the lipid bilayer were observed on both fracture faces. Intramembranous particles were similarly aggregated in myocardium ischemic for 2 hours; however, the number of nicks were greatly increased on the P and E fracture faces. These structural alterations, which were undetected in thin sections, are likely to be associated with altered function in the sarcolemma of ischemic myocardium.
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