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  • Title: Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances.
    Author: Shimada M, Sato C, Hoshi Y, Yamada Y.
    Journal: Phys Med Biol; 2009 Aug 21; 54(16):5057-71. PubMed ID: 19652290.
    Abstract:
    Our newly developed method using spatially and time-resolved reflectances can easily estimate the absorption coefficients of each layer in a two-layered medium if the thickness of the upper layer and the reduced scattering coefficients of the two layers are known a priori. We experimentally validated this method using phantoms and examined its possibility of estimating the absorption coefficients of the tissues in human heads. In the case of a homogeneous plastic phantom (polyacetal block), the absorption coefficient estimated by our method agreed well with that obtained by a conventional method. Also, in the case of two-layered phantoms, our method successfully estimated the absorption coefficients of the two layers. Furthermore, the absorption coefficients of the extracerebral and cerebral tissue inside human foreheads were estimated under the assumption that the human heads were two-layered media. It was found that the absorption coefficients of the cerebral tissues were larger than those of the extracerebral tissues.
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