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  • Title: Families of H/ACA ncRNA molecules in trypanosomatids.
    Author: Doniger T, Michaeli S, Unger R.
    Journal: RNA Biol; 2009; 6(4):370-4. PubMed ID: 19652533.
    Abstract:
    H/ACA molecules are small nucleolar RNAs (snoRNAs) that guide the conversion of a uridine into a pseudouridine. This modification is crucial for ribosomal RNA (rRNA) function. In addition, H/ACA RNA also function in ribosomal RNA processing. Unlike the double hairpin structure of H/ACA molecules in other organisms, H/ACA molecules in Trypanosomes have a single hairpin structure. Here we describe the repertoire of the 46 published H/ACA molecules in Trypanosoma brucei, as well as identify the orthologous counterparts in other Trypanosomatids enlarging the H/ACA collection in this family to over 300.
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