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  • Title: Cryptosin induces backbone structural changes in cardiac Na+ and K+ dependent adenosinetriphosphatase.
    Author: Venkateswara RR, Dipak D, Banning JW, Vaidyanathan CS.
    Journal: Biochem Int; 1990 Oct; 22(2):287-94. PubMed ID: 1965277.
    Abstract:
    Cryptosin, a new cardenolide, was found to preferentially bind to Na,K-ATPase enzyme (7), which is believed to be the ouabain binding site on cardiac sarcolemmal membrane. CD spectral studies revealed that cryptosin, in the presence of Na+ and Mg++ ions, bind to Na,K-ATPase and induce a dose-dependent change in the backbone structure of cardiac Na,K-ATPase.
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