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  • Title: Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
    Author: Xiping Z, Jun F, Jie Z, Bingyan Y, Jing M, Wei Z, Jing Y, Penghui J, Wenqin Y, Ninnin Z, Jiao H.
    Journal: Inflamm Res; 2010 Jan; 59(1):31-9. PubMed ID: 19655231.
    Abstract:
    OBJECTIVE: To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). METHODS: Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed. RESULTS: In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05). CONCLUSIONS: Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
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