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  • Title: Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.
    Author: Anselmi L, Sementa AR, Borgiani L, Banderali A, Rovida S.
    Journal: Pathologica; 1990; 82(1082):653-62. PubMed ID: 1965612.
    Abstract:
    By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.
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