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  • Title: Intestinal cholecystokinin controls glucose production through a neuronal network.
    Author: Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK.
    Journal: Cell Metab; 2009 Aug; 10(2):99-109. PubMed ID: 19656488.
    Abstract:
    Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating insulin levels. Furthermore, we show that duodenal CCK-8 requires the activation of the gut CCK-A receptor and a gut-brain-liver neuronal axis to lower glucose production. Finally, duodenal CCK-8 fails to lower glucose production in the early onset of high-fat diet-induced insulin resistance. These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding.
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