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  • Title: Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes.
    Author: Bakker-Woudenberg IA, Lokerse AF, ten Kate M.
    Journal: Scand J Infect Dis Suppl; 1990; 74():54-7. PubMed ID: 1965866.
    Abstract:
    The antiviral effect of ganciclovir and foscarnet encapsulated in liposomes was studied against cytomegalovirus in human embryonic lung fibroblast cells. Substantially greater activity (3.5-fold and 38-fold respectively) in terms of inhibition of virus replication intracellularly was found compared to that seen with non-encapsulated antiviral agents, and liposome encapsulation did not result in increased cytotoxicity.
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