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  • Title: Synthesis and characterization of new ferrocene peptide conjugates.
    Author: Drexler C, Milne M, Morgan E, Jennings M, Kraatz HB.
    Journal: Dalton Trans; 2009 Jun 14; (22):4370-8. PubMed ID: 19662315.
    Abstract:
    Three classes of diamine linked ferrocene (Fc)-conjugates were prepared and their properties were investigates in solution and the solid state: (a) acyclic diamine-linked 1,n'-Fc conjugates, (b) acyclic diamine-linked 1,n'-Fc peptide conjugates, and (c) cyclic 1,n'-Fc-peptide diamine conjugates. In all cases, the synthetic procedure started from 1,1'-ferrocenecarboxylic acid methyl ester or 1,1'-ferrocene dicarboxylic acid or their amino acid conjugates followed by coupling with diaminoalkanes. The resulting conjugates exhibit H-bonding as is evident by temperature and, in some cases, concentration-dependent NMR shifts and in the solid-state structure of one of the conjugates. Our studies show that the structural properties of Fc-diamine-linked systems are different from those of the related cystamine conjugates, presumably due to the enhanced flexibility of the conjugates.
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