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  • Title: Myocardial beta-adrenoceptors and inhibitory G-proteins in myocardial biopsies and in explanted hearts from patients with dilated cardiomyopathy.
    Author: Böhm M, Gierschik P, Schnabel P, Erdmann E.
    Journal: Cardioscience; 1990 Jun; 1(2):109-17. PubMed ID: 1966374.
    Abstract:
    Cardiac beta-adrenoceptors and the alpha-subunits of the inhibitory guanine-nucleotide binding proteins (Gi alpha) were determined in myocardial biopsies and in larger samples of explanted hearts from patients with dilated cardiomyopathy. The myocardium of one non-failing heart was studied for comparison. There were fewer beta-adrenoceptors in right and left ventricular samples from hearts with dilated cardiomyopathy than in the non-failing myocardium. The number of beta-adrenoceptors determined by equilibrium saturation experiments closely correlated with their density as measured by a saturating concentration of the radioligand 125Iodocyanopindolol in myocardial biopsies. Using the 32P-ADP-ribosylation of a 40kDa membrane protein catalyzed by pertussis toxin, an increase of Gi alpha could also be shown in both myocardial biopsies and explanted hearts.
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