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  • Title: [Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].
    Author: Zhang HQ, Zhao JJ, Zhao YR, Guan QB, Gao L, Song HD.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2009 Aug; 25(8):699-701. PubMed ID: 19664392.
    Abstract:
    AIM: Killer cell immunoglobulin-like receptor (KIR) can modulate the activity of NK and T lymphocyte. To investigate whether the KIR genotype possessing a susceptibility to Graves disease (GD). METHODS: Using PCR-SSP to detect KIR genotype in 96 GD patients and 96 randomly selected healthy controls. RESULTS: The genotype frequency of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4- was significantly higher in the patient group compared to that of the control group (6.25% vs 0%, P<0.05). Genotype of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4+ is the most prevalent in the controls (28.13% vs 10.42%, P<0.01). Genotypes without activating KIR genes have higher frequency in patient group. CONCLUSION: The difference of KIR genotypes between GD patients and healthy controls may explain the pathogenesis of GD.
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