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  • Title: Cell alterations induced by the large T-antigens of SV40 and polyoma virus.
    Author: Dilworth SM.
    Journal: Semin Cancer Biol; 1990 Dec; 1(6):407-14. PubMed ID: 1966492.
    Abstract:
    The large T-antigens of SV40 and polyoma virus are nuclear, multifunctional proteins that are essential for replication of the respective viruses. They can also 'transform' cells in culture to varying extents; both can immortalise primary cells, and SV40 large T can additionally induce full transformation. Recently, p105Rb, the protein product of the anti-oncogene RB-1, has been shown to interact with both large T-antigens. SV40 large T-antigen also binds to a p105Rb related protein, p107. SV40 large T differs from that of polyoma virus in its ability to associate with another anti-oncogene product, p53. The significance of these properties to the transforming potential of both viruses is considered.
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