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  • Title: A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene.
    Author: Messaritou G, Leptourgidou F, Franco M, Skoulakis EM.
    Journal: FEBS Lett; 2009 Sep 03; 583(17):2934-8. PubMed ID: 19665025.
    Abstract:
    14-3-3 proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14-3-3zeta (leo), encoding two isoforms LEOI and LEOII, and 14-3-3epsilon. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14-3-3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA-interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila.
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