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  • Title: The effect of portacaval shunt on plasma lipids and lipoproteins in swine.
    Author: Nestruck AC, Lussier-Cacan S, Bergseth M, Bidallier M, Davignon J, Marcel YL.
    Journal: Biochim Biophys Acta; 1977 Jul 20; 488(1):43-54. PubMed ID: 196656.
    Abstract:
    Plasma lipids and lipoprotein composition and distribution were studied in fasted miniature swine prior to and at 5 and 19 weeks following portacaval shunt surgery or a sham operation. Plasma triacylglycerol and cholesterol levels were significantly reduced in the portacaval shunt swine at 5 weeks. These reductions were accompanied by significant decreases in the plasma very low density lipoprotein (d less than 1.006), low density lipoprotein (d = 1.02-1.07) and high density lipoprotein (d = 1.09-1.21) levels. The very low density lipoprotein were shown depleted in lipids and the low density lipoprotein was a cholesterol-depleted, triacylglycerol-enriched particle. No changes in the composition of the high density lipoprotein were observed. These reductions and changes in composition were maintained until killing at 19 weeks post-surgery.
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