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  • Title: Bilirubin and morphine glucuronidation is not inhibited by a cyclic-AMP mediated mechanism in murine liver.
    Author: Bánhegyi G, Garzó T, Mészáros G, Antoni F, Mandl J.
    Journal: Acta Biochim Biophys Hung; 1990; 25(1-2):87-92. PubMed ID: 1966648.
    Abstract:
    Several reactions of the Ist and IInd phase of biotransformation have been reported to be under a negative cyclic-AMP dependent control. Conjugation of bilirubin and glucuronidation of morphine were investigated in isolated mouse hepatocytes and in mouse hepatocyte microsomes, respectively. N6,O2-dibutyryl cyclic-AMP did not inhibit conjugation of bilirubin in isolated hepatocytes. ATP and the dissociated catalytic subunit of the cyclic-AMP dependent protein kinase did not influence the glucuronidation of morphine, while inhibited the formation of p-nitrophenol glucuronide in microsomes prepared from isolated mouse hepatocytes.
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