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  • Title: [Microfluidic cell culture array chip for drug screening assays].
    Author: Zheng Y, Wu J, Shao J, Jin Q, Zhao J.
    Journal: Sheng Wu Gong Cheng Xue Bao; 2009 May; 25(5):779-85. PubMed ID: 19670650.
    Abstract:
    We developed a novel microfluidic cell chip, which enabled drug delivery, fluid control and cell co-culture. The device consisted of an array of 6x6 cell culture chambers, a drug gradient generator and fluidic control valves. Micro-dam structures of the chambers were able to trap cells while loading and drug gradient network generated drug gradient of 6 different concentrations. Also we applied hydraulic valves to control the microfluid and simulate the microenvironment of cells. We had investigated the viability of co-culturing cells in the chip and the ability for drug screening. This microfluidic cell chip has the potential in cell-based research of high throughput drug screening.
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