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  • Title: Neuromuscular block by circulating D-tubocurarine residue following uptake and distribution.
    Author: Yang E, Lee C.
    Journal: Can Anaesth Soc J; 1977 Jul; 24(4):468-74. PubMed ID: 196721.
    Abstract:
    Serum concentration of d-tubocurarine decreases rapidly after intravenous injection because of uptake and distribution. The circulating residue of an ED 50 dose of d-tubocurarine five minutes after injection will produce no block in a previously unexposed neuromuscular junction. To produce a 50 per cent block with the circulating d-tubocurarine residue in a previously unexposed neuromuscular junction requires an initial injection of 2.5 x ED 50 dose. Five minutes after a dose 5 to 6 times the ED 50, the plasma d-tubocurarine residue is sufficient to produce a total block.
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