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  • Title: Expression of the V beta 5.1 gene by murine peripheral T cells is controlled by MHC genes and skewed to the CD8+ subset.
    Author: Liao NS, Maltzman J, Raulet DH.
    Journal: J Immunol; 1990 Feb 01; 144(3):844-8. PubMed ID: 1967275.
    Abstract:
    We have examined the usage of the V beta 5.1 region in peripheral T cell populations of several mouse strains by measuring V beta 5.1 transcript levels. The results show that V beta 5.1 is expressed predominantly by CD8+ T cells in mice of several MHC haplotypes. This finding suggests that V beta 5.1 may confer restriction to class 1 molecules present in these strains. Interestingly, however, T cells expressing V beta 5.1, like those expressing V beta 17a and V beta 11, are clonally deleted from both CD4 and CD8 subsets in mice that express MHC IE molecules. The latter result implies that V beta 5.1 confers reactivity to a class 2 molecule (IE). These results are discussed in terms of positive selection and clonal deletion. Finally we provide evidence that genes in the K or A regions of the MHC also control V beta 5.1 usage.
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